| Sancia | Derived from the Latin word for sacred. |
| Sandia | A place of meeting or a junction. |
| Sanita | little healthy girl |
| Santiago | Named for Saint James |
| Santos | Derived from the Spanish word for saints. |
| Sara | Arabic form of Sarah; From the name SARAH; Pure. Happy.; Precious; Princess; Soul. |
| Sarita | Goddess Durga; River; Little princess; Princess; River |
| Saturnin | Belonging to the planet Saturn. |
| Saturnina | Dedicated to the Roman god Saturn. |
| Saul | Asked for; Asked, lent, a grave. Demanded, lent, ditch, death.; Asked: inquired of God. The Hebrew name of the Apostle Paul.; Borrowed; Desired.; Prayed for |
| Savana | A sacred ritual or sacrifice |
| Savanah | One who performs a sacrifice |
| Savanna | From the open plain |
| Savannah | From the open plain |
| Sayda | A lady of high social standing. |
| Sebastiano | Spanish form of Sebastian revered |
| Segunda | A name meaning the second born child. |
| Segundo | Born as the second child. |
| Sein | A name meaning to exist. |
| Seina | A name meaning holy grace. |
| Selena | Variant of Celine. |
| Senalda | A wise and noble commander. |
| Senon | Derived from the Greek name Zenon. |
| Senona | A feminine form of the name Senon. |
| Serafina | Fiery ones of the angels. |
| Serena | Calm; tranquil.; Having a peaceful disposition; Quiet; Quiet calm; Serene; Serene, Calm |
| Severo | Strict: restrained. |
| Sevilla | the name of a city |
| Seville | Named after the Spanish city. |
| Sevy | Short form of Sebastian, derived from the Latin Sebastianus, meaning 'from Sebastia'. |
| Shoshana | A name meaning a beautiful lily flower. |
| Silverio | Variant of Sylvanus referring to the mythological Greek god of trees. |
| Silvino | Variant of Sylvanus referring to the mythological Greek god of trees. |
| Simona | A name meaning one who listens. |
| Socorro | Spanish name meaning relief. |
| Sofia | Derives From Sophia; From the name SOPHIA; Wise |
| Solana | A name meaning sunshine or wind. |
| Soledad | A name meaning solitude or lone. |
| Soledada | A variant meaning lonely or solitary. |
| Sonora | Pleasant sounding |